. 2021 Jun 4;19(6):e3001295. doi: 10.1371/journal.pbio.3001295

Table 2. List of contacts between CCK1R and G proteins.

CCK1R/Gα_S contacts
Nonbonded contacts			Nonbonded contacts continued
Gαs	CCK1R	Distance (Å)	Gαs	CCK1R	Distance (Å)
R38	R150^ICL2	3.07	Q390	N374^8.47	2.93
H41	L147^ICL2	3.61	Q390	T76^2.39	3.72
H41	R150^ICL2	3.58	Y391	V311^6.33	3.82
D215	Q148^ICL2	2.99	Y391	R139^3.50	3.66
V217	Q148^ICL2	3.34	L393	M373^7.56	3.22
D354	A302^6.24	3.59	L393	R310^6.32	3.69
Y358	N304^6.26	3.80	L394	K375^8.48	3.34
F376	L147^ICL2	3.56	L394	R378^8.51	3.01
R380	L147^ICL2	3.85	R389	R376^8.51	3.48
R380	P146^ICL2	3.89
R380	E235^8.48	3.37	Hydrogen bonds
R380	C144^3.55	2.63	Gαs	CCK1R	Distance (Å)
I383	L147^ICL2	3.66	R38	R150^ICL2	3.07
Q384	P146^ICL2	3.68	R38	R150^ICL2	3.29
Q384	I143^3.54	2.93	D215	Q148^ICL2	2.99
Q384	E235^5.64	3.63	R380	C144^3.55	2.63
R385	N304^6.26	3.82	H387	A142^3.53	2.75
H387	A142^3.53	2.75	Q390	N374^8.47	3.34
H387	P146^ICL2	3.58
H387	R150^ICL2	3.40	Salt bridges
L388	I143^3.54	3.77	Gαs	CCK1R	Distance (Å)
L388	K308^6.30	3.66	R380	E235^5.64	3.37
CCK1R/mGsqi contacts
Nonbonded contacts			Nonbonded contacts continued
mGsqi	CCK1R	Distance (Å)	mGsqi	CCK1R	Distance (Å)
R38	R150^ICL2	3.69	Y391	R139^3.50	3.68
R38	T154^4.38	3.57	Y391	A142^3.53	3.63
R38	R150^ICL2	3.27	Y391	Q153^ICL2	2.34
R38	V151^ICL2	2.98	N392	N374^8.47	3.32
R38	T154^4.38	3.48	N392	T76^2.39	3.49
R39	V151^ICL2	3.38	L393	V311^6.33	3.25
L41	L147^ICL2	3.67	L393	R139^3.50	3.42
L41	R150^ICL2	3.41	L393	L315^6.37	3.79
V217	L147^ICL2	3.75
K380	L147^ICL2	3.69
I383	P146^ICL2	3.62	Hydrogen bonds contacts
I383	L147^ICL2	3.74	mGsqi	CCK1R	Distance (Å)
I383	R150^ICL2	3.64	R38	R150^ICL2	3.27
L384	I143^3.54	3.26	R38	V151^ICL2	2.98
N387	A142^3.53	3.72	N387	A142^3.53	3.38
R389	R376^8.49	3.57	R389	R376^8.49	3.57
E390	T76^2.39	3.38	Y391	Q153^ICL2	2.34

CCK, cholecystokinin; CCK1R, cholecystokinin type 1 receptor.