Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 May 31;59(1):49. doi: 10.3892/ijo.2021.5229

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Liao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

AMD3100 enhances the antitumor effect of doxorubicin in an orthotopic OS mouse model. (A) Macroscopic appearance of OS tumors in the tibia of C3H mice after 8 consecutive injections of PBS, 5 mg/kg AMD3100, 1 mg/kg doxorubicin and AMD3100 plus doxorubicin. (B) The body weight of the mice in each group was measured at every injection, and the growth curve was obtained. (C) The volume and weight of the tumors in the four treatment groups were determined. (D) The expression levels of C-X-C motif chemokine receptor 4, beclin 1, light chain 3B and P-glycoprotein in tumor tissues were detected by immunohistochemical staining, and the areal density was quantified and subjected to statistical analysis. (E) The expression of p-PI3K, p-AKT and p-mTOR in tumor tissues was detected by immunohistochemical staining, and the areal density was quantified and subjected to statistical analysis. ^*P<0.05, ^**P<0.01, ^****P<0.0001. OS, osteosarcoma; p-, phosphorylated.