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. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: Hypertension. 2021 Apr 5;77(6):2084–2093. doi: 10.1161/HYPERTENSIONAHA.120.16252

Figure 4. Pharmacological blockade of the NET formation by Cl-amidine reduced the rate of aneurysm rupture.

Figure 4.

There is no difference in the incidence of aneurysm between vehicle-treated control mice and CI-amidine-treated mice (A). There are significantly decreased aneurysm rupture rate (B) and SAH rate (C) in CI-amidine-treated mice as compared to vehicle-treated control mice. A significantly increased symptom-free survival rate (D) is seen in CI-amidine-treated mice as compared to control mice. There is no difference in blood pressure between the two groups (E). Fisher’s exact test was used to analyze the incidences of aneurysm formation and subarachnoid hemorrhage (B and C). Log-rank (Mantel-Cox) test was used for the analysis of survival rate (D). Multiple t-test was used for blood pressure analysis (E). Data are expressed as means ± standard deviation. ∗ P < 0.05.