Table 2.
Clinical features of cases of recurrent GBS disease.
| Country | ID | Sex | BW (g) | GA (w) | DM | 1st episode | 2nd episode | 3rd episode | Isolates | Colonisation | Breast milk | Outcome | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| age (d) | GBS | Abx | age (d) | GBS | Abx | age (d) | GBS | Abx | Sero-type | MLST | Infant | Mo-ther | GBS | Cessa-tion | Imm | Seq | ||||||
| Germany | 1 | F | 565 | 23 | CS | 1 | B | 10 | 48 | B | 12 | 124 | B | 21 | N/A | N/A | pos | pos | neg | Yes | N | no |
| Germany | 2 | F | 670 | 25 | CS | 41 | B | 14 | 84 | B | 21 | – | – | – | N/A | N/A | pos | neg | neg | No* | ^ | no |
| Germany | 3 | F | 1230 | 27 | V | 46 | B | 7 | 62 | B | 10 | – | – | – | N/A | N/A | neg | neg | pos | Yes** | N | no |
| Germany | 4 | F | 590 | 23 | N/A | 150 | B | 9 | 166 | B/CSF | 42 | – | – | – | N/A | N/A | neg | N/A | pos | Yes** | ^^ | DD |
| Germany | 5 | F | 1732 | 32 | CS | 35 | B | 14 | 64 | B | 14 | – | – | – | N/A | N/A | N/A | neg | pos | Yes | N | no |
| Germany | 6 | F | 1470 | 32 | CS | 28 | B/CSF | 21 | 63 | B | 14 | – | – | – | N/A | N/A | N/A | N/A | pos | Yes | N | no |
| Germany | 7 | F | 2890 | 39 | V | 10 | B | 10 | 25 | B | 14 | – | – | – | N/A | N/A | N/A | neg | neg | No | N/A | no |
| Germany | 8 | F | 4320 | 37 | V | 1 | B | 15 | 25 | B/CSF | 14 | – | – | – | N/A | N/A | neg | pos | N/A | No | N/A | no |
| Germany | 9 | M | 3020 | 37 | CS | 1 | B | 14 | 21 | B | 14 | – | – | – | N/A | N/A | pos | pos | N/A | No | N/A | no |
| Germany | 10 | M | 3020 | 35 | V | 20 | B/CSF | 15 | 60 | B | 14 | – | – | – | N/A | N/A | pos | neg | N/A | No | N/A | no |
| Germany | 11 | F | 4190 | 41 | V | 3 | B | 7 | 24 | B | 14 | – | – | – | N/A | N/A | N/A | neg | N/A | No | ^^^ | no |
| Germany | 12 | M | 1125 | 28 | CS | 48 | B/CSF | 19 | 74 | B/CSF | 19 | – | – | – | III | 17 | neg | pos | pos | Yes | N | no |
| Germany | 13 | N/A | 1920 | 31 | CS | 47 | B | 10 | 60 | B | 9 | – | – | – | N/A | N/A | N/A | N/A | N/A | N/A | ^^ | no |
| UKROI | 14 | F | 1082 | 27 | N/A | 39 | B | 10 | 59 | B | 14 | – | – | – | Ia | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| UKROI | 15 | M | 3770 | 39 | V | 0 | B | 7 | 23 | B | 14 | – | – | – | III | 17 | N/A | neg | N/A | N/A | N/A | N/A |
| UKROI | 16 | M | 3350 | 42 | N/A | 11 | B | 7 | 25 | B | 40 | – | – | – | III | 17 | N/A | N/A | N/A | N/A | N/A | N/A |
| UKROI | 17 | M | 2020 | 31 | N/A | 73 | B | 5 | 84 | B | 42 | – | – | – | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| UKROI | 18 | M | 770 | 23 | N/A | 1 | B | 9 | 30 | B/CSF | 21 | – | – | – | Ib | new | N/A | pos | N/A | N/A | N/A | D |
| UKROI | 19 | M | 1070 | 30 | V | 26 | B/CSF | N/A | 54 | B/CSF | 21 | – | – | – | V/III | 17 | N/A | N/A | N/A | N/A | N/A | N/A |
| UKROI | 20 | M | 1490 | 29 | N/A | 37 | B | 10 | 59 | B/CSF | 21 | – | – | – | III | 17 | N/A | N/A | N/A | N/A | N/A | N/A |
| UKROI | 21 | M | 3150 | 40 | N/A | 11 | B/CSF | 7 | 38 | B/CSF | 21 | – | – | – | III | 17 | N/A | N/A | N/A | N/A | N/A | N/A |
| UKROI | 22 | M | 3900 | 41 | N/A | 16 | B | 7 | 28 | B | 14 | – | – | – | III | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| UKROI | 23 | M | 600 | 23 | N/A | 0 | B | 7 | 82 | B | N/A | – | – | – | III | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| UKROI | 24 | M | 1620 | 31 | N/A | 8 | B | 14 | 41 | B | 14 | 69 | B | 14 | III | 23 | N/A | N/A | N/A | N/A | N/A | N/A |
| UKROI | 25 | F | 1790 | 32 | CS | 0 | B | 10 | 23 | B/CSF | 21 | – | – | – | V | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
AN, Abnormal; C, Cellulitis; CS, Ceasarean section; D, Death; DD, Developmental delay; Imm, Immunology; Me, Meningitis; N, Normal; N/A, Not available; S, Sepsis; Seq., Sequelae; V, Vaginal delivery, *Pasteurized, **Temporary (restarted after maternal decolonization), ^: lack of Memory B cells and neutropenia, ^^: transient hypogammaglobulinemia, ^^^: reduced CH50 activity (<10%).