Myofibrillar protein fractional synthesis rate (FSR; expressed as %·h-1) over a 3-hour postexercise period following a work-matched bout of maximal concentric knee extensor contractions and ingestion of either a postexercise protein-polyphenol (PP; n = 9) or isocaloric maltodextrin placebo (PLA; n = 9) drink (A), and the subsequent 9-hour overnight period, beginning with ingestion of either a prebed PP (n = 9) or isocaloric maltodextrin PLA (n = 9) drink (B). Postexercise and overnight periods correspond to between 24 and 27 hours, and 27 and 36 hours, respectively, following 300 maximal unilateral eccentric knee extensor contractions (damaged, black bars), while the contralateral leg rested (control, white bars). FSRs are calculated from body water deuterium enrichment as precursor pool. Data are presented as means, with individual responses shown with open circles (○). Statistical analysis was performed with separate 2-factor analysis of variance (ANOVA) and the postexercise vs overnight period was compared with a 3-factor ANOVA. *Difference between postexercise and overnight periods; #difference between damaged and control legs. One symbol, P < 0.05.