Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Overview of the study design. Single-nucleotide variations associated with thyrotropin (TSH) were used as instrumental variables to identify candidate mediators for the TSH risk on atrial fibrillation (AF). Two-sample mendelian randomization (MR) was used to identify mediators associated with AF. Multivariable MR was then used to determine the effect that adjusting for the mediators had on the association between TSH and AF.
