Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Apr 13;7(4):000563. doi: 10.1099/mgen.0.000563

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 The Authors

This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial License.

PMC Copyright notice

Fig. 4. — Phylogenetic analysis of bacterial NeuB and NeuB homologues. The NeuB HMM profile, reconstructed with the sequences from the KEGG database, was used to mine NeuB sequences and their homologues in the UniprotKB database. A total of 13 941 sequences were recovered and the presence of the NeuB domain was confirmed by comparison with the CDD database. The NeuB domains (~250 aa) were separated from the rest of the sequences and used in phylogenetic analysis. The total neighbour-joining tree was calculated using SWeeP [38], an alignment-free clustering tool. (a) The coloured clades represent the pathogenic organisms identified through the GOLD and KEGG databases. NeuB sequences and homologues were identified based on an unambiguous E.C. number. The coloured dots represent sequences identified as: (b) neuraminic acid synthase (Neu), (c) pseudaminic acid synthase (Pse) and (d) legionaminic acid synthase (Leg). (e) SAF domain identified by Interpro. (f) All previous E.C. numbers identified. Bars, 0.1 amino acid substitutions per site per million years.