Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jun 16;7(25):eabg8685. doi: 10.1126/sciadv.abg8685

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.

PMC Copyright notice

Fig. 5 — (A) Binding interfaces at the rim (left) and core (right) of the complex. Each interface is colored on the surface of the G protein and interacting residues in the receptor are shown as spheres (Cα) and sticks (side chains). (B) Residue-residue interactions at the rim of the binding interface. (C) Left: Structure of the α5 hook and ICL4 in the [6P4]CCL5•CCR5 complex. Key residues are shown as sticks. Right: Comparison between the α5 hook and ICL4 in the G_i-bound receptors CCR5, neurotensin type 1 (NT1R), and μ-opioid (μOPR).