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. 2021 Feb 1;117(7):1746–1759. doi: 10.1093/cvr/cvab024

Figure 4.

Figure 4

NLRP3 inflammasome upregulation increases the susceptibility to obesity-related AF inducibility. (A) Representative recordings of lead-2 surface ECG and intracardiac electrograms in WT and NLRP3−/− mice after 10 weeks’ feeding of NC or HFD, respectively. (B) The incidence of pacing-induced reproducible AF. *P < 0.05 determined by Fisher’s exact test. (C) The maximum duration of pacing-induced AF. *P < 0.05, **P < 0.01 determined by Kruskal–Wallis test. (C) Representative M-mode echocardiograph. (D–F) Summary of ejection fraction (EF%, D), end-systolic diameter (ESD, E), and end-diastolic diameter (EDD, F) of WT and NLRP3−/− mice after 10 weeks’ feeding of NC or HFD, respectively. P > 0.05 determined by Sidak test following one-way ANOVA.