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. 2021 Feb 1;117(7):1746–1759. doi: 10.1093/cvr/cvab024

Figure 5.

Figure 5

NLRP3 inflammasome contributes to the evolution of a pro-arrhythmic substrate for AF. (A) Representative optical di-4-ANEPPS signal and activation maps from optical mapping study. (B) Summary of conduction velocity (CV) in right atrium, and (C) atrial effective refractory period (AERP) in atria of WT and NLRP3−/− mice after 10 weeks’ feeding of NC or HFD, respectively. (D) Action potential duration (APD) at 20%, 50%, 70%, and 90% repolarization in right atrium. The relative level of Kcna5 mRNA (E) and Kv1.5 protein (F) in atria of WT and NLRP3−/− mice after 10 weeks’ feeding of NC or HFD, respectively. *P < 0.05, **P < 0.01 determined by Sidak test following one-way ANOVA. (G) Representative western blots and quantification of Kv1.5 protein level in atrial tissues of non-obese control (Ctl) and obese (Ob) patients. P = 0.09 determined by Student’s t-test.