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. 2021 May 6;20(6):e13370. doi: 10.1111/acel.13370

FIGURE 2.

FIGURE 2

PC4 induced accelerated ageing phenotypes in multiple tissues of PC4 transgenic knock‐in mouse. (a) Life span analysis of PC4(+/+) and PC4(KI/KI) mouse. (b) Cataract incidence in PC4(+/+) and PC4(KI/KI) mice with age. (c–e) Analysis of fat level (c), bone density (d), and spine angles (e), heart‐to‐body weight ratio (f), skin dermal or adipose thickness (g and h), renal lesions (i and j), P16 level in skin and kidney (k–m), routine blood analysis (n–t), CD4+ to CD8+ T cell ratio (u) and percentage of memory T cells (v) in 18‐month‐old PC4(+/+) and PC4(KI/KI) mouse. For (a and b), n = 17 (PC4(+/+)), n = 15 (PC4(+/+)). For (c and d), n = 4. For (e, h, j and l), n = 5. For (f), each symbol represents one mouse. For (m), n = 3. For (n–t), n = 11 (PC4(+/+)), n = 10 (PC4(+/+)). For (u and v), n = 5 (PC4(+/+)), n = 6 (PC4(+/+)). For (a), Kaplan–Meier survival analysis. For (b–v), two‐tailed Student's t‐test. *p < 0.05