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. Author manuscript; available in PMC: 2021 Jun 16.
Published in final edited form as: Respir Physiol Neurobiol. 2020 Apr 5;277:103438. doi: 10.1016/j.resp.2020.103438

Table 1.

Respiratory parameters before and following AF-454 or vehicle administration.

AF-454 AF-454 Vehicle
(5 mg/kg) (10 mg/kg) (n = 5)
(n = 5) (n = 7)
Baseline 10 min 20 min Baseline 10 min 20 min Baseline 10 min 20 min
fR (breaths min −1) 102 ± 3 101 ± 2 99 ± 4 104 ± 5 104 ± 5 101 ± 7 99 ± 6 94 ± 4 90 ± 6
VT (ml kg −1) 9.1 ± 0.3 9.2 ± 0.2 8.9 ± 0.4 8.5 ± 0.5 9.1 ± 0.8 9 ± 1 9.5 ± 0.9 10.1 ± 0.8 10.4 ± 1.5
V̇E (ml kg−1 min −1) 928 ± 44 926 ± 42 884 ± 53 892 ± 88 945 ± 127 940 ± 152 953 ± 112 984 ± 114 984 ± 172

Abbreviations: fR: Respiratory frequency, VT: Tidal volume, V̇E: Minute ventilation. For each time point, 10-minute epochs were considered for analysis. Data were analysed by repeated measures one-way ANOVA. No differences were found between the different time-points within each treatment group.