Table 1.
Association between ADM expression levels and clinical/molecular data across public datasets.
| Variable | GSE6891 (n=68) | GSE14468 (n=459) | Beat AML (n=142) | TCGA-LAML (n=135) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n (%) | median [min-max] | p | n (%) | median [min-max] | p | n (%) | median [min-max] | p | n (%) | median [min-max] | p | ||
| Age | - | 0.034 | 0.653 | 0.056 | |||||||||
| <60-years | – | – | 383 (83.8) | 159.8 [57.7-3848.3] | 60 (42.3) | 9.5 [0.2-313.9] | 72 (53.3) | 1.3 [0.0-23.1] | |||||
| ≥60-years | 63 (100.0) | 196.7 [93.4-4451.3] | 74 (16.2) | 238.2 [98.4-442.9] | 82 (57.7) | 11.4 [0.3-151.7] | 63 (46.7) | 2.0 [0.0-57.1] | |||||
| missing | 5 | 2 | – | – | |||||||||
| FAB | 0.001 | <0.001 | 0.057 | 0.591 | |||||||||
| M0 | 2 (3.6) | 229.7 [188.7-270.6] | 18 (4.1) | 135.3 [80.5-477.7] | 4 (7.8) | 4.0 [1.2-6.1] | 14 (10.5) | 2.1 [0.0-5.5] | |||||
| M1 | 11 (19.6) | 122.7 [97.0-206.5] | 97 (22.2) | 134.8 [57.7-3396.9] | 6 (11.8) | 1.3 [1.0-118.2] | 35 (26.1) | 1.2 [0.0-12.4] | |||||
| M2 | 23 (41.1) | 148.1 [92.4-1024.0] | 123 (28.2) | 147.0 [71.0-2936.7] | 5 (9.8) | 6.4 [0.9-63.6] | 38 (28.4) | 1.3 [0.1-17.2] | |||||
| M4 | 9 (16.1) | 221.3 [172.4-4451.3] | 83 (19.0) | 205.1 [84.5-3848.3] | 16 (31.4) | 19.0 [3.5-159.1] | 29 (21.6) | 2.0 [0.1-12.8] | |||||
| M5 | 10 (17.9) | 448.6 [166.6-4451.3] | 109 (24.9) | 183.6 [83.9-4482.2] | 19 (37.3) | 4.3 [0.3-151.7] | 15 (11.2) | 1.1 [0.0-57.1] | |||||
| M6 | 1 (1.8) | 843.4 | 7 (1.6) | 171.3 [123.6-849.2] | – | – | 2 (1.5) | 2.3 [1.9-2.7] | |||||
| M7 | – | – | – | – | 1 (2.0) | 5.9 | 1 (0.8) | 1.4 [1.4-1.4] | |||||
| missing | 12 | 22 | 91 | 1 | |||||||||
| Cytogenetic group | 0.063 | <0.001 | 0.001 | 0.001 | |||||||||
| t(8;21) | 3 (5.0) | 104.0 [96.3-126.2] | 32 (9.8) | 137.2 [92.4-451.9] | 3 (2.1) | 7.3 [0.9-15.1] | 7 (5.3) | 0.2 [0.1-1.0] | |||||
| inv(16)/t(16;16) | 4 (6.7) | 516.6 [182.3-2256.7] | 33 (10.1) | 210.1 [125.4-2164.8] | 9 (6.4) | 18.9 [5.1-98.7] | 10 (7.6) | 1.9 [1.2-7.0] | |||||
| NK | 23 (38.3) | 188.7 [96.3-4451.3] | 139 (42.4) | 149.1 [57.7-3848.3] | 75 (53.6) | 7.5 [0.2-313.9] | 60 (45.5) | 1.2 [0.0-57.1] | |||||
| CK | 4 (6.7) | 178.1 [92.4-4451.3] | 27 (8.2) | 133.4 [95.7-2740.1] | 19 (13.6) | 35.6 [1.2-130.8] | 18 (13.6) | 3.4 [0.3-17.2] | |||||
| KMT2A-r | 1 (1.7) | 179.8 | 15 (4.6) | 116.2 [84.5-1782.9] | 8 (5.7) | 2.0 [0.3-39.3] | 8 (6.1) | 0.5 [0.0-1.8] | |||||
| Other | 25 (41.7) | 229.1 [114.6-2019.8] | 82 (25.0) | 169.5 [74.5-3304.0] | 26 (18.6) | 13.8 [0.4-159.1] | 29 (22.0) | 1.9 [0.0-12.8] | |||||
| missing | 8 | 131 | 2 | 3 | |||||||||
| FLT3-ITD | 0.023 | 0.009 | 0.062 | 0.001 | |||||||||
| FLT3-ITD+ | 18 (26.5) | 145.5[96.3-1024.0] | 112 (28.3) | 144.5 [57.7-2091.0] | 27 (20.3) | 4.2 [0.4-118.2] | 27 (20.5) | 0.4 [0.0-23.1] | |||||
| FLT3-ITD− | 50 (73.5) | 247.3 [92.4-4451.3] | 283 (71.7) | 167.7 [68.1-3848.3] | 106 (79.7) | 14.5 [0.2-313.9] | 105 (79.6) | 1.9 [0.0-57.1] | |||||
| missing | – | 64 | 9 | 3 | |||||||||
| NPM1 status | 0.127 | 0.249 | 0.064 | 0.034 | |||||||||
| NPM1-mut | 20 (29.4) | 151.2 [96.3-2019.8] | 135 (34.2) | 313.9 [57.7-3743.1] | 37 (27.8) | 4.2 [0.6-313.9] | 38 (28.8) | 0.6 [0.0-57.1] | |||||
| NPM1-wt | 48 (70.6) | 244.0 [92.4-4451.3] | 260 (65.8) | 164.9 [68.1-3848.3] | 96 (72.2) | 13.8 [0.2-159.1] | 94 (71.2) | 1.8 [0.0-16.8] | |||||
| missing | – | 64 | 9 | 3 | |||||||||
| FLT3-ITD/NPM1 | 0.004 | 0.070 | 0.086 | 0.009 | |||||||||
| −/wt | 40 (58.8) | 244.7 [92.4-4451.3] | 218 (55.2) | 168.9 [68.1-3848.3] | 81 (60.9) | 15.1 [0.2-159.1] | 84 (63.6) | 2.0 [0.0-16.8] | |||||
| +/wt | 8 (11.8) | 281.9 [97.0-1024.0] | 42 (10.6) | 147.5 [83.3-2091.0] | 15 (11.3) | 8.9 [0.4-118.2] | 10 (7.6) | 0.8 [0.2-12.4] | |||||
| −/mut | 10 (14.7) | 305.0 [120.3-2019.8] | 65 (16.5) | 163.2 [71.0-3743.1] | 25 (18.8) | 9.4 [0.6-313.9] | 21 (15.9) | 1.5 [0.0-57.1] | |||||
| +/mut | 10 (14.7) | 123.8 [96.3-166.6] | 70 (17.7) | 140.6 [57.7-1758.3] | 12 (9.0) | 2.7 [0.8-46.5] | 17 (12.9) | 0.3 [0.0-23.1] | |||||
| missing | – | 64 | 9 | 3 | |||||||||
| ELN 2010 | 0.448 | 0.255 | 0.104 | 0.114 | |||||||||
| Favorable | 11 (18.3) | 221.3 [96.3-2256.7] | 115 (35.3) | 172.4 [67.2-2179.8] | 38 (27.1) | 10.8 [0.5-313.9] | 40 (30.8) | 1.3 [0.0-57.1] | |||||
| Int-I | 19 (31.7) | 148.1 [96.3-4451.3] | 89 (27.3) | 140.1 [57.3-3875.1] | 49 (35.0) | 7.7 [0.2-151.7] | 37 (28.5) | 1.2 [0.1-23.1] | |||||
| Int-II | 18 (30.0) | 201.6 [117.8-2019.8] | 74 (22.7) | 160.9 [70.0-3327.0] | 26 (18.6) | 10.2 [0.3-159.1] | 22 (16.9) | 1.5 [0.0-12.8] | |||||
| Adverse | 12 (20.0) | 237.3 [92.4-4451.3] | 48 (14.7) | 150.1 [83.7-2019.8] | 27 (19.3) | 21.8 [0.4-130.8] | 31 (23.9) | 2.8 [0.3-17.2] | |||||
| missing | 8 | 133 | 2 | 5 | |||||||||
CK, complex karyotype; Int, Intermediate; ITD, internal tandem duplication; KMT2A-r, KMT2A-rearranged; min-max, minimum-to-maximum value; mut, mutated; n, number; NK, normal karyotype; p, p value; wt, wild-type.
p ≤ 0.05 are highlighted as bold text.