Figure 2.

Msr1 is dispensable for systemic VSV dissemination and innate immune responses

(A) The RNA viremia in the whole blood of WT and Msr1^−/− mice, Msr1^+/−, and Msr1^−/− littermates infected with VSV, assessed by quantitative RT-PCR, N = 6 mice/genotype in each experiment. The VSV RNA is expressed as a fold change over limit of detection (LOD)s.

(B) The serum levels of type I IFN and inflammatory cytokines (IFN-α, IFN-γ, TNF-α, IL-10, CXCL-10, IL-1β, IL-6) in Msr1^+/− and Msr1^−/− littermates after VSV infection, assessed by multiplex ELISA, N = 6 mice/genotype. All the data are presented as mean ± S.E.M., and statistical significance is analyzed by non-parametric Mann-Whitney U tests.