Fig. 5.

Effects of ATPγS and 2-methylthio-ATP, with and without preceding administration of NF023 (100 μM) and PPADS (50 μM) on tension of human prostate tissues. Application of ATPγS or 2-methylthio-ATP in cumulative concentrations was started 30 min following administration of NF023 or PPADS, or of equivalent amounts of water (solvent) in controls. Shown are means ± SD from four independent series, each with prostate tissues from n = 5 (a), n = 5 (b), n = 6 (c), and n = 5 (d) different patients, where tissue from each prostate was allocated to the control and antagonist groups in each single experiment