Fig. 1.

Slit lamp photographs and anterior segment coherence tomography (AS-OCT) scans of Case 1 during the follow-up in the right eye (OD) (A1, A2, C1, C2, E1 and E2) and in the left eye (OS). (B1, B2, D1, D2, F1 and F2)

At baseline, clear cornea in both eyes (OU) (A1 and B1) and homogenous signal intensity in corneal epithelium with an intact Bowman layer (BL) at the central cornea (red box) and paracentral cornea (yellow box) on AS-OCT (A2 and B2). After the second infusion of belantamab mafodotin on day 42, microcystic-like epithelial changes (MECs) with no central cornea involvement in OU were observed (C1 and D1). The presence of homogenous signal intensity and clear BL at the central cornea (red box), with increased heterogeneous signal intensity and hyperreflective lesions (yellow arrows) in the corneal epithelium in OU, BL disruptions (yellow arrow heads) in OD and increasing corneal epithelial thickness (CET) at paracentral cornea (yellow box) in OU (C2 and D2). On day 82, there were mild residual keratopathies OU (E1 and F1), which improved as compared to day 42. There were no change of epithelial intensity and CET at central cornea (red box) in OU. At paracentral cornea (yellow box), hyperreflective lesions in epithelium and epithelial intensity improved to homogeneity and CET decreased to baseline level in OU (E2 and F2). (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)