Table 1.
IC50 for P1 and P3 acting on cancer cells in the apo- and holo-forms.
| IC50 (µmol/L) | HT1080 | MDA-MB-231 | A549 | HeLa |
|---|---|---|---|---|
| P1 | 5.58a (5.41–5.77) | 5.83b (4.82–7.04) | 4.20a (3.71–4.65) | 2.22a (1.37–3.61) |
| P1-Cu2+ | 5.31 (4.91–5.75) | 3.92b (3.54–4.33) | 2.15 (1.94–2.30) | 2.17 (1.32–3.60) |
| P3 | 26.01 (23.7–28.6) | 17.5b (11.8–26.0) | 21.6 (20.4–23.7) | 18.1b (10.8–30.4) |
| P3-Cu2+ | 5.52 (5.03–6.05) | 5.25b (4.32–6.37) | 2.99 (2.60–3.34) | 1.97 (1.24–3.12) |
The range of concentrations corresponding to the 95% confidence interval are provided in parentheses.
aFrom this work. Comparison to data in Lin et al.39 is provided in the text.
bFirst data point at 0.16 µmol/L was not used to extract IC50 values due to large deviation from the trend line but all data points are displayed in Fig. 1.