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. 2021 Jun 16;11:12713. doi: 10.1038/s41598-021-92041-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Association between cell free DNA (cfDNA) levels on admission and the severity and outcomes of stroke. Association between cfDNA levels on admission and stroke severity (A), short term outcome of stroke (B), long-term outcome of stroke (C), and therapy-associated intracerebral hemorrhage (D). cfDNA, cell free DNA; ICH, intracerebral hemorrhage; NIHSS, National Institutes of Health Stroke Scale, mRS, modified Rankin Scale, **p < 0.01, *p < 0.05 [(A) Kruskal–Wallis with Dunn-Bonferroni post hoc test, (B–D) Mann–Whitney U test].