Table 1.

MiRNAs and their putative targets and signaling pathways that are relevant to GC cell proliferation and apoptosis.

MiRNA	Target genes	Signaling pathway	References
Up
miR-21	15-PGDH	PGE2/PI3K/Akt/Wnt/β-catenin	[10]
	PTEN	PTEN/PI3K/mTOR	[11, 12]
miR-27a	SFRP1	Wnt/β-catenin	[21]
miR-103	KLF4		[91]
miR-106a	FAS		[29]
miR-107	NF1		[92]
	PTEN	PI3K	[16]
miR-146a	SMAD4		[93]
miR-151-5p	P53	Notch1	[94]
miR-192/215	APC	Wnt/β-catenin	[22]
miR-194	SUFU	Wnt/β-catenin	[23]
miR-200c	P27Kip1		[95]
miR-558	HPSE		[96]
miR-590-5p	RECK	Akt/ERK; STAT3	[71]
miR-208a-3p	PDCD4		[97]
miR-423-3p	Bim		[98]
miR-454	CHD5		[99]
miR-520c	IRF2		[100]
miR-3174	ARHGAP10		[24]
Down
miR-15a	Bmi-1		[101]
miR-15a-3p/ miR-16-1-3p	Twist1		[102]
miR-16-5p	Smad3		[103]
miR-26b	KPNA2	KPNA2/c-Jun	[7]
miR-29b	KDM2A	RUNX3/miR-29b/KDM2A	[104]
miR-29c-3p	KIAA1199	FGFR4/Wnt/β-catenin; EGFR	[105]
miR-31	HDAC2		[106]
miR-101	MCL1/ZEB1		[30]
miR-127	MAPK4		[107]
miR-132-3p	MUC13	Akt/ ERK	[108]
miR-135a	KIFC1		[109]
miR-143-3p	AKT2		[8]
miR-154	DIXDC1	Wnt	[17]
miR-194	KDM5B		[110]
miR-199a/b-3p	PAK4	PAK4/MEK/ERK	[111]
miR-202-3p	Gli1		[112]
miR-203a	E2F3		[113]
miR-203	Slug		[114]
miR-204	CKS1B/CXCL1/GPRC5A		[115]
miR-337-3p	MMP-14		[116]
miR-338-3p	SOX5	Wnt/β-catenin	[18]
miR-375	YAP1/TEAD4/CTGF	Hippo	[117]
miR-495	Akt; mTOR	PI3K/Akt/mTOR	[13]
miR-511	TRIM24	PI3K/Akt; Wnt/β-catenin	[15]
miR-520f-3p	SOX9	Wnt/β-catenin	[19]
miR-524-5p	MMP-2/MMP-9		[118]
miR-584-3p	MMP-14		[119]
miR-647	SRF	SRF/MYH9	[120]
miR-873	STRA6	Wnt/β-catenin	[20]
miR-1284	EIF4A1		[25]
miR-3978	LGMN		[121]