a Huh-7 cells were exposed to 0, 2, 4, or 8 μM EM-2 for 24 h. The protein expression levels of proteins associated with endoplasmic reticulum stress were detected by Western blotting. b Huh-7 cells were exposed to 0, 2, 4, or 8 μM EM-2 for 24 h. The mRNA expression levels of ER stress-related pathway genes were analyzed by RT-qPCR. All experiments were performed in three independent replicates (*P < 0.05; **P < 0.01; ***P < 0.001).