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. 2020 Oct 14;42(7):1171–1179. doi: 10.1038/s41401-020-00543-x

Fig. 9. Proposed mechanism: EZH2 regulates the expression of FOXC1 by mediating H3K27me3 in breast cancers.

Fig. 9

FOXC1 is highly expressed in TNBC. The expression of FOXC1 is epigenetically regulated by H3K27me3 and associated with doxorubicin resistance and a poor prognosis in patients with TNBC.