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. 2021 Jun 16;12(7):624. doi: 10.1038/s41419-021-03922-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Relative proteasomal activities in heart samples with or without OSTN overexpression (n = 6). B Representative western blot images and statistical results (n = 6). C Representative immunofluorescence images of Ub-positive protein aggregates in diabetic hearts with or without OSTN overexpression (n = 6). D Relative mRNA levels related to endoplasmic reticulum stress in diabetic hearts (n = 6). E Representative western blot images and statistical results (n = 6). F Caspase3 activity in heart samples (n = 6). G, H Statistical data of the TUNEL-positive nuclei and collagen deposition (n = 6). I Cardiac functional parameters (n = 8). Data represent mean ± SD. *P < 0.05 versus the matched group, NS indicates no significance.