Table 2.
Statistical measures and brain coordinates of the identified brain region components.
| Component | Reference component (Pearson r2) | Loadings direction | LME (initiation age) | Brain region label | L/R Volume in cm3 | Brodmann area | L/R Max z-value (MNI coordinates) | ||
|---|---|---|---|---|---|---|---|---|---|
| t (df) | pFDR | R2/R2 whole model | |||||||
| COI-1 | Temporal (0.68) | Early > late | −0.474 (96) | 0.64 | 0.002/0.019 | Insula | 8.4/7.6 | 13, 40 | 5.4 (−38, 8, 4)/4.3 (44, −28, 18) |
| Inferior frontal gyrus | 5.2/3.4 | 13, 44, 45, 47 | 5.4 (−40, 22, 2)/3.6 (26, 14, −24) | ||||||
| Extra nuclear | 1.5/0.4 | 13, 47 | 5.0 (−36, 20, 0)/3.2 (36, 0, 10) | ||||||
| Precentral gyrus | 0.6/1.0 | 6, 13, 44 | 4.4 (−40, 8, 8)/3.5 (48, −6, 6) | ||||||
| Superior temporal gyrus | 7.2/6.6 | 13, 21, 22, 38, 41 | 3.9 (−42, 14, −22)/3.9 (30, 14, −26) | ||||||
| Parahippocampal gyrus | 1.0/0.3 | 28, 34 | 3.3 (−20, −6, −20)/2.8 (20, −8, −18) | ||||||
| COI-2 | Frontal (0.72) | Late > early | 0.656 (93) | 0.64 | 0.016/0.047 | Superior frontal gyrus | 6.3/6.0 | 6, 8, 9, 10, 11 | 4.3 (−26, 40, 34)/3.8 (26, 44, 32) |
| Middle frontal gyrus | 8.0/4.0 | 8, 9, 10, 46, 47 | 4.0 (−30, 40, 32)/3.6 (30, 44, 30) | ||||||
| Medial frontal gyrus | 1.1/0.8 | 9, 10 | 3.6 (−24, 36, 32)/2.9 (6, 54, 24) | ||||||
| COI-3 | Brainstem (0.38) | Early > late | – | – | – | Uncus | 1.5/1.2 | 20, 28, 36, 38 | 5.9 (−28, 0, −42)/4.0 (26, −6, −36) |
| Middle temporal gyrus | 1.5/0.4 | 21 | 5.0 (−32, 8, −42)/3.2 (44, −70, 16) | ||||||
| Superior temporal gyrus | 1.3/0.1 | 22, 38 | 4.6 (−24, 8, −40)/2.6 (52, 14, −18) | ||||||
| Inferior parietal lobule | 1.5/0.0 | 40 | 3.8 (−38, −44, 58)/NA (0, 0, 0) | ||||||
| COI-9 | Cerebellum (0.59) | Early > late | −2.758 (100) | 0.02 | 0.079/0.100 | Cerebellar tonsil | 4.0/3.8 | – | 12.2 (0, −56, −46)/10.5 (4, −56, −46) |
| Inferior semilunar lobule | 3.1/1.2 | – | 11.7 (−4, −58, −50)/10.9 (4, −58, −50) | ||||||
| Nodule | 0.8/1.2 | – | 8.5 (−4, −56, −38)/9.0 (0, −54, −38) | ||||||
| Uvula | 1.3/1.7 | – | 7.7 (−4, −64, −42)/7.2 (0, −62, −38) | ||||||
| Culmen | 1.0/1.2 | – | 4.3 (−2, −50, −6)/4.6 (2, −50, −6) | ||||||
Bold italic refers to negative component regions.
LME linear mixed effects model.