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. 2021 Jun 16;12(7):625. doi: 10.1038/s41419-021-03907-1

Fig. 7. SHH signaling pathway is downregulated in ALS.

Fig. 7

a–d Analysis of SHH (a), PTCH1 (b), SMO (c), and GLI1 (d) expression levels in spinal cord biopsies of human healthy control (HC) and ALS patients; data are shown as standard box-and-whiskers of n = 10 HC and n = 10 ALS subjects; *p-value < 0.05 versus HC; two-sided Student’s t-test. e Interaction network of six selected genes (i.e. query) of SHH signaling pathway (in red) and the top-20 interactors genes (in white); interactions are shown as based on curated databases (red lines) or experimentally determined (black lines). f Enrichment KEGG analysis of genes showed in panel (e); significant pathways related to SHH signaling in humans are shown as −log of false discovery rate (FDR).