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. 2021 Jun 16;12:3653. doi: 10.1038/s41467-021-23939-7

Fig. 8. Postnatal onset of Tsc1 haploinsufficiency in PV cells induces premature putative synapse formation.

Fig. 8

af Representative immunostained sections of somatosensory cortex labeled for PV/GFP (blue/green) and gephyrin (red) in P22 PV-Cre;RCE;Tsc1+/+ (ac) and PV-Cre;RCE;Tsc1flox/+ mice (df). White arrowheads indicate PV/Gephyrin colocalized puncta (c and f). Scale bar: 5 μm. g Quantification of PV/GFP-Gephyrin colocalized puncta (Welch’s t-test, *p = 0.0121). Number of mice: n = 5 for PV-Cre;RCE;Tsc1+/+ and n = 7 for PV-Cre;RCE;Tsc1flox/+. Data represent mean ± SEM. Source data are provided as a Source Data file.