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. 2020 Aug 18;42(7):1124–1138. doi: 10.1038/s41401-020-0497-0

Fig. 3. BAH treatment normalized the expression of genes associated with fibrosis in the TNBS model.

Fig. 3

a RNA from colon tissue was used to determine the expression of genes involved in fibrosis by PCR array. Heat maps showed the significantly upregulated (green) or downregulated (red) genes in TNBS + vehicle or TNBS + BAH compared with control + vehicle. b The mRNA expression of fibrosis-related genes (Tnc, Il-13, Timp-1, Il-1β, Ccl3, Mmp-3, Mmp-8, and Mrc-1) was quantified by qPCR and normalized to the levels of Gapdh. Data represent the mean ± SEM, and significance was determined by one-way ANOVA followed by Dunnett’s post hoc test. The results are expressed as the mean ± SEM (n = 3–7 animals per group) *P < 0.05, **P < 0.01, and ***P < 0.001 for TNBS + vehicle vs control + vehicle; #P < 0.05, and ##P < 0.01 for TNBS + BAH vs TNBS + vehicle.