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. 2020 Aug 18;42(7):1124–1138. doi: 10.1038/s41401-020-0497-0

Fig. 9. BAH exerts its functions systemically but not intrarectally.

Fig. 9

a BAH improved the histological score and collagen content when administered by oral gavage but not when administered rectally (original magnification ×20). The quantification is shown as the mean ± SEM (n = 6–8 animals per group), and significance was determined by one-way ANOVA followed by Tukey’s post hoc test. ***P < 0.001 for DSS + vehicle vs control + vehicle; ##P < 0.01, and ###P < 0.001 for DSS + BAH or DSS + DMOG vs DSS + vehicle. b Mean plasma concentration-time profile and main pharmacokinetic parameters (c) of BAH after PO (20 mg/kg) and IV (2 mg/kg) administration in mice. The results are expressed as the mean ± SD (n = 3 animals per group). d BAH treatment normalized the expression of Hif-1α protein in colon during TNBS insult (original magnification ×20). Data represent the mean ± SEM, and significance was determined by one-way ANOVA followed by the Tukeyʼs post-hoc test. Results are expressed as mean ± SEM (n = 4 animals per group). ***P < 0.001 TNBS + Vehicle vs Control + Vehicle; ###P < 0.001 TNBS + BAH vs TNBS + Vehicle.