Subject	Cancer Research
Specific subject area	Real-world retrospective analysis of treatment outcomes in advanced lung cancer
Type of data	Table Figure
How data were acquired	Electronic health records in the Flatiron Health oncology database Instruments: SAS Enterprise Guide 7.1 and R 3.6.2
Data format	Analyzed
Parameters for data collection	Electronic health records for patients aged ≥18 years with confirmed stage III–IV non-small cell lung cancer who received either first-line immunotherapy monotherapy or single-agent immunotherapy combined with chemotherapy on or after January 1, 2016 were analyzed; patients were excluded if they had <2 documented visits on/after initial non-small cell lung cancer diagnosis, EGFR-/ALK-positive tumors, or tumors with unknown histology.
Description of data collection	Death information was derived from 3 data sources (electronic health records, Social Security Death Index, and commercial death dataset). Progression data were abstracted from unstructured clinician notes using Flatiron-defined methodology. Disease progression was defined as a distinct episode in which the treating physician concluded there had been growth or worsening in disease, as determined by clinic visit notes. The start date of the 1L therapy was defined as the first episode of an eligible therapy that was given after or up to 14 days before the date of diagnosis with advanced NSCLC.
Data source location	Institution: Flatiron Health, Inc. Country: United States
Data accessibility	The data for this analysis were provided by Flatiron Health and are not publicly available. Interested parties are encouraged to contact DataAccess@flatiron.com regarding license agreements and methods to obtain the deidentified data.
Related research article	D. Waterhouse, J. Lam, K.A. Betts, L. Yin, S. Gao, Y. Yuan, J. Hartman, S. Rao, S. Lubinga, D. Stenehjem, Real-world outcomes of immunotherapy-based regimens in first-line advanced non-small cell lung cancer, Lung Cancer. 156 (2021) 41-49. DOI:https://doi.org/10.1016/j.lungcan.2021.04.007