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. 2021 Jun 3;15:100349. doi: 10.1016/j.ynstr.2021.100349

Fig. 4.

Fig. 4

Cofilin downregulation in NA core prevents the enhancement of AMPAR surface expression in stressed rats exposed to cocaine.

(A) Experimental design. (B) Representative western blots of GluR1 surface fraction and GluR1 surface plus internal. ɑ-tubulin was used as loading control for Western blot experiments. (C) AMPAR subunit GluR1 in rats pretreated with shCtrl or shcofilin into the NA core, 45 min after a saline injection, analyzed by two-way ANOVA and Bonferroni's post-hoc comparison, n = 9–10 in each group. (D) AMPAR subunit GluR1 in rats pretreated with shCtrl or shcofilin into the NA core, 45 min after a cocaine injection, analyzed by two-way ANOVA and Bonferroni's post-hoc, n = 8–10 in each group. Data are expressed as mean ± SEM of the number of determinations depicted in each graphic. *p < 0.05, compared with S/shcofilin. #*p < 0.05, compared with NS/shcofilin. #p < 0.05, compared with NS/shCtrl.