. 2021 Jun 3;59:27–36. doi: 10.1016/j.breast.2021.05.014

Table 2.

Unadjusted and adjusted Hazard Ratios for overall survival in patients diagnosed with breast cancer at Chris Hani Baragwanath and Charlotte Maxeke Johannesburg Academic Hospitals between May 2015 and September 2017.

			Unadjusted		Adjusted∗
	Number at risk	Number of deaths	Hazard Ratio (95% CI)	p-value	Hazard Ratio (95% CI)	p-value
Age at diagnosis (years)	1016	457
<50			1.00 (Reference)		1.00 (Reference)
≥50			1.10 (0.91–1.33)	0.326	1.09 (0.87–1.36)	0.450
Linear trend			1.01 (1.00–1.01)	0.067	1.01 (1.00–1.02)	0.015
HIV status	982	437
Negative			1.00 (Reference)		1.00 (Reference)
Positive			1.50 (1.22–1.85)	<0.001	1.77 (1.37–2.28)	<0.001
Stage at Diagnosis	1007	456
Early stage (Stage I/II)			1.00 (Reference)		1.00 (Reference)
Advanced Stage (Stage (III/IV)			3.85 (3.09–4.79)	<0.001	3.71 (2.92–4.72)	<0.001
Receptor Status^a
ER positive	986	449	0.68 (0.55–0.83)	<0.001	0.71 (0.57–0.88)	0.002
PR positive	984	448	0.65 (0.54–0.78)	<0.001	0.74 (0.60–0.90)	0.003
Her2-positive	964	439	1.16 (0.94–1.43)	0.166	0.94 (0.75–1.18)	0.601
Receptor Subtype^b	954	436
Luminal A			1.00 (Reference)		1.00 (Reference)
Luminal B			1.84 (1.32–2.58)	<0.001	1.88 (1.30–2.72)	0.001
Her2-enriched			1.76 (1.06–2.93)	0.029	1.46 (0.84–2.56)	0.182
Triple negative			2.52 (1.72–3.69)	<0.001	2.65 (1.75–4.01)	<0.001
BMI (kg/m²)	939	411	0.99 (0.98–1.00)	0.206	0.99 (0.98–1.00)	0.178
Employment status	1002	447
Employed			1.00 (Reference)		1.00 (Reference)
Unemployed			1.13 (0.94–1.37)	0.182	1.17 (0.96–1.44)	0.129
Education^c	998	445
Primary or lower			1.00 (Reference)		1.00 (Reference)
Secondary			0.65 (0.53–0.81)	<0.001	0.75 (0.59–0.95)	0.017
Tertiary			0.49 (0.34–0.73)	<0.001	0.78 (0.51–1.20)	0.256

∗Adjusted for age at diagnosis (continuous), BMI (continuous), stage at diagnosis (early vs advanced), receptor subtype (luminal A vs luminal B, Her2-enriched, triple negative), employment status (employed vs unemployed) and education (primary vs secondary, tertiary). Receptor Status adjusted for age at diagnosis (continuous), BMI (continuous), stage at diagnosis (early vs late), employment status (employed vs unemployed) and education (primary vs secondary, tertiary).

Reference for each receptor is the receptor negative.

Receptor subtypes were defined by immunohistochemistry as follows: Luminal A (ER +, PR +, HER2 -, Ki 67 < 14%), Luminal B (ER +, PR +/−, HER2 -, Ki 67 > 14% or ER +, PR +/−, HER-2 +, any Ki 67), HER2-enriched (ER/PR -, HER2 +, any Ki 67) and Triple negative breast cancer (ER/PR/HER2 -, any Ki 67).

Primary education refers to the first 7 years of school education and secondary as the first 12 years.