FIGURE 1.

A summary of brain areas likely to be involved in mediating both pain and mood and arousal complaints in migraine via structural and functional connections. Thalamocortical pathways that modulate sensory and cognitive processing are also involved. Neurotransmitters implicated in these areas in migraine are shown in green. *Specific cortical areas implicated include dorsolateral prefrontal cortex, orbitofrontal cortex, anterior cingulate cortex, and the primary somatosensory cortex. Areas highlighted in red are likely to also have a role with their associated neurotransmitters in fatigue and mood.