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. 2021 Jun 3;15:678102. doi: 10.3389/fnbeh.2021.678102

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Copyright © 2021 Kamens, Miller, Caulfield, Zeid, Horton, Silva, Sebastian, Albert, Gould, Fishbein, Grigson and Cavigelli.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Morphine-induced acute behavioral stimulation and sensitization in adult C57BL/6J and BALB/cJ mice. Daily mean locomotor distance (cm) ±SEM are presented in panels: (A) C57BL/6J males, (C) C57BL/6J females, (E) BALB/cJ males, and (G) BALB/cJ females. Within-subject morphine stimulant and sensitization scores (mean ± SEM) are presented in panels: (B) C57BL/6J males, (D) C57BL/6J females, (F) BALB/cJ males, and (H) BALB/cJ females. Chronic saline animals are on the left side and chronic drug treated mice on the right side in each panel, with sensitization in the chronic drug treated mice shown in the far right-hand bars. N = 5–8 per stress and drug condition. *p < 0.05 for the stress × drug group interaction; #p < 0.05 for the main effect of drug group; $p < 0.05 for the main effect of stress; &p = 0.055 for the main effect of stress.