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. 2020 Jan 10;8(4):569–579. doi: 10.1016/j.gendis.2020.01.004

Figure 2.

Figure 2

Nuclear translocation of cTnIR193H/cTnI and their transcriptional activities to PDE4D. (A) Western blotting for detecting the nuclear protein and total cTnI or cTnIR193H in primary neonatal cardiomyocytes overexpressing cTnI or cTnIR193H, and column graph for the ratios of nuclear to total protein reflecting the translocation ability. 30ug nuclei and 100ug whole cells extraction were used to make H3 similar (B) 293T cells expressing cTnI or cTnIR193H for dual-luciferase reporter gene assays to test cTnI or cTnIR193H transcriptional activities to PDE4D. *P < 0.05 relative to vector group; n = 6 per group.