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. 2020 Jan 10;8(4):569–579. doi: 10.1016/j.gendis.2020.01.004

Figure 4.

Figure 4

HDAC1 represses PDE4D expression via histone deacetylation. Primary neonatal cardiomyocytes overexpressing HDAC1 were used for these experiments. (A) PDE4D protein level in blank group, NC group, and HDAC1 overexpression group (OE-HDAC1). (B) ChiP assays for detecting the enrichment of HDAC1, acH3K4 and acH3K9 among the three groups. The results are expressed as mean ± SD. Statistical significance was determined by ANOVA followed by LSD tests. *P < 0.05 as relative to NC group; n = 6 per group.