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. 2020 Jan 10;8(4):569–579. doi: 10.1016/j.gendis.2020.01.004

Figure 7.

Figure 7

EGCG inhibits cTnIR193H-HDAC1 interactions but not HDAC1 activity. Primary neonatal cardiomyocytes overexpressing cTnIR193H with or without EGCG treatment were used for these experiments. (A) CoIP assays for detecting the interaction between HDAC1 and cTnIR193H in the presence and absence of EGCG, and column graph for the ratio of immunoprecipitated-proteins reflecting the interaction strength. (B) Western blot assays for detecting the free HDAC1 in the supernatant. (C) HDAC1 activities. The results are expressed as mean ± SD. Statistical significance was determined by ANOVA followed by LSD tests. *P < 0.05; n = 6 per group.