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. 2020 Feb 1;8(4):493–508. doi: 10.1016/j.gendis.2020.01.015

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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ITGA2 downregulation-altered genes and clusters. (A) Heatmap of differentially expressed 195 genes >1.5 fold change upon ITGA2 KD via siITGA2 (see Table S1), with most being downregulated (top and middle rows of 169 genes) and a small portion of upregulated genes (bottom rows of 26 genes). (B) Top 20 gene clusters enriched by ITGA2 KD, colored by p-values. The Metascape gene list analyses were carried out with the ontology sources of KEGG Pathway, GO, Reactome, Canonical Pathways, and CORUM. (C-E) Heatmap of genes in representative pathways of cell cycle and regulation of protein kinase activity (C), lipid metabolism (D), and wound healing and cell migration (E), with representative genes CCND1 and ACLY shown in C and D, respectively.