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. 2020 Feb 1;8(4):493–508. doi: 10.1016/j.gendis.2020.01.015

Figure 7.

Figure 7

ITGA2 pathway is associated with outcomes of the patients with breast cancer. (A-C) Breast Cancer Kaplan–Meier Plotter analyses of RFS correlated with CCND1 expression (a, Log rank P = 0.043, n = 701), and ACLY expression (b, Log rank P = 0.001, n = 407), and OS associated with miR-206 expression (c, Log rank P = 0.002, n = 159) in ER-breast cancer with best cut off. (D-F) KM plots of RFS correlation with ITGA2 expression in ER- (Log rank p = 0.0406, n = 189) (D), grade 3 ER- (Log rank P = 0.048, n = 347) (E), and all grade 3 (Log rank P = 0.037, n = 444) (F) breast cancer, with best cut off selected in Breast Cancer Kaplan–Meier Plotter analyses. (G) Breast cancer miner plot of any-event (AE) free survival association with ITGA2 expression in TNBC. Log rank P = 0.02, n = 1258, median cut off. (H) Box plot for differential ACLY and CCND1 expression levels between clustered and single CTCs of breast cancer patients and PDXs (GSE109761 and GSE111065).16,31 Wilcox t test P = 0.004 and 0.024 for ACLY and CCND1 comparisons, respectively. (I) Schematic CD49b signaling pathway induced by extracellular matrix factors such as collagen I fibers that result in the phosphorylation of FAK and upregulation of CCND1 and ACLY levels to promote proliferation, stemness, and metastasis of TNBC.