Table 4.

Dose–response between antidepressants and response to drug.

	Binomial Bayesian		Normal Bayesian		One-stage (frequentist)		Binomial Bayesian with drug clusters
	Mean	SD	Mean	SD	Mean	SE	Mean	SD
$B_1$	0.0214	0.0024	0.0210	0.0037	0.0209	0.0025	0.0213	0.0036
$B_2$	−0.0397	0.0070	−0.0396	0.0085	−0.0376	0.0060	−0.0387	0.0079
$\tau$	0.0087	0.0028	0.0072	0.0031	${\tau }_1=0.0103 {\tau }_2=0.0115$	–	${\tau }_{\mathrm{within}}=$0.0076  ${\tau }_{\mathrm{between}}=0.0050$	0.0028 0.0040
$\rho$	−0.4782	0.4952	−0.2488	0.5652	−1	–	${\rho }_{\mathrm{within}}=-0.3611 {\rho }_{\mathrm{between}}=-0.1064$	0.5153  $0.5508$

Note: Dose is measured as fluoxetine-equivalent in mg/day. The model is fitted with restricted cubic splines and assuming random dose–response coefficients.