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. 2021 Jun 3;13:639529. doi: 10.3389/fnagi.2021.639529

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Copyright © 2021 Li, Zhou, Zhu, Li, Gao, Li, Luo, Wu, Tian and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Interaction effects of group and sex in regional topological metrics of brain networks (p < 0.05). (A–E) Compared with HCs, male aMCI patients showed decreased Cp_nodal and Le_nodal of the right orbital frontal lobe, whereas male AD patients showed decreased Cp_nodal of the right middle temporal gyrus, decreased E_nodal of the left middle cingulum, and decreased Le_nodal of the left postcentral gyrus compared with HCs and aMCI patients. (E–G) Compared with HCs, the Le_nodal and Cp_nodal of the left postcentral gyrus was increased in female AD patients. Compared with aMCI patients, the E_nodal of the right precuneus was significantly increased in female AD patients. *p < 0.05.