Table 2.
Summary of the dysregulated and functional role of lncRNAs in different cancers.
| lncRNA | Cancer type | Expression | Target Gene/factor | Signaling pathway | Function | Ref |
|---|---|---|---|---|---|---|
| GAS5 | Oral squamous cell carcinoma | Up | Akt, E-cadherin, PCNA, cyclinD1, N-cadherin, vimentin, snail1 | PTEN | Cell proliferation, migration, invasion, and EMT | 167 |
| MEG3 | Papillary carcinoma | Down | Rac1 | Rac1 pathway | Suppresses migration and invasion | 168 |
| GAS5 | Breast cancer | Down | Notch-1 | AKT/mTOR | Cell proliferation | 169 |
| PVT1 | Prostate cancer | Up | Caspase-3, caspase-9, c-Myc | EMT | Cancer growth, apoptosis | 170 |
| ZFAS1 | Head and neck squamous cell carcinoma | Up | ZNFX1, miR-150-5p, EIF4E | TGF-β, VEGF, JAK/ STAT, PDGF, PI3K, p53, p38, Ras, Toll receptor, Wnt |
EMT, proliferation, migration, invasion, apoptosis, cell adhesion, signal transduction, differentiation, angiogenesis, oxidative stress response |
171 |
| ANRIL | Prostate cancer | Up | CBX7 | – | EMT, proliferation, migration | 172 |
| BANCR | Gastric cancer | Up | NF-κB1 | – | Proliferation, migration, invasion | 173 |
| H19 | Hepatic cancer | Up | p57, ANG | HIF1α | Proliferation | 174 |
| TUG1 | Non-small-cell lung cancer | Down | p53, HOXB7 | AKT and MAPK | EMT, migration | 175 |
| HOTAIR | Gastric Cancer | Up | PRC2 | HGF/C-Met/Snail | EMT, migration, invasion, apoptosis | 176 |
| PVT1 | Non-small-cell lung cancer | Up | EZH2 | Mdm2-p53 | Proliferation | 177 |
| CCAT1 | Gastric cancer | Up | P27, p21, p16, caspase-3, Bax, Bcl-2 | ERK/MAPK | Proliferation | 178 |
| CCAT2 | Colorectal cancer | Up | MYC, miR-20a | WNT | – | 179 |
| HOTAIR | Esophageal squamous cell cancer | Up | WIF-1 | Wnt/β-catenin | Migration, invasion, | 180 |
| MALAT1 | Colorectal cancer | Up | β-catenin | Wnt/β-catenin | Proliferation, migration | 181 |
| ROR | Nasopharyngeal cancer | Up | Vimentin, N-cadherin | P53 | Proliferation, migration, invasion, EMT | 182 |
| PTENP1 | Hepatic cancer | Down | PTEN, PHLPP (a negative AKT regulator), ULK1, ATG7, p62 | PI3K/AKT | Apoptosis | 183 |
| ATB | Breast cancer | Up | ZEB1, ZNF-217 | TGF-β | EMT | 184 |
| WT1-AS | Hepatic cancer | Down | WT1 | JAK/STAT3 | Apoptosis | 185 |
| AFAP1-AS1 | Lung cancer | Up | AFAP1, RhoA, Rac2, Rab10, Rab11a, Pfn1, RhoC, Rab11 b, LIM, Lasp1 | Actin cytokeratin | Migration, invasion | 186 |
| ATB | Prostate cancer | Up | E-cadherin, ZO-1, cyclin E, cyclin D1, ZEB1, ZNF217, N-cadherin, vimentin | ERK and PI3K/AKT | Proliferation, EMT | 187 |
| ANRIL | Gastric cancer | Up | PRC2, E2F1 | mTOR and CDK6/E2F1 | Proliferation | 188 |
| CASC11 | Colorectal cancer | Up | C-Myc | WNT/β-catenin | Proliferation, metastasis | 189 |
| LINC00963 | Prostate cancer | Up | EGFR, p-AKT | EGFR | Proliferation, migration metastasis | 190 |
| LOC400891 | Prostate cancer | Up | PTEN, vimentin, β-catenin, Twist, Snail |
PI3K-AKT-mTOR | Proliferation, migration, invasion | 191 |
| PCAT5 | Prostate cancer | Up | ERG | Cell proliferation pathways | Proliferation, migration, invasion | 192 |