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. 2020 Mar 19;8(4):438–447. doi: 10.1016/j.gendis.2020.03.003

Figure 3.

Figure 3

Macroautophagy independent lysosomal degradation of insulin granules and Golgi. The fate of secretory granules is controlled by the accumulation induced starvation-induced nascent granule degradation (SINGD) in the megaphagocytic active cells and the Golgi membrane associated degradation (GOMED) in the macroautophagy dysfunctional cells. SINGD pathway promotes autophagic lysosomal degradation of newborn granules, which leads to lysosomal recruitment and mTORC1 activation, thus inhibiting macroautophagy.