TABLE 8.
W (n = 7) | W-EX (n = 7) | SHR (n = 7) | SHR-EX (n = 7) | ||
JNK | Phosphorylated | 1.00 ± 0.31 | 1.02 ± 0.31 | 3.46 ± 1.23* | 3.38 ± 1.61# |
Total | 1.00 ± 0.47 | 0.91 ± 0.40 | 1.54 ± 0.59 | 1.09 ± 0.27 | |
p38 | Phosphorylated | 1.00 ± 0.37 | 0.85 ± 0.27 | 1.10 ± 0.18 | 1.17 ± 0.49 |
Total | 1.00 ± 0.22 | 0.76 ± 0.22 | 3.38 ± 1.79* | 3.36 ± 2.08 | |
ERK | Phosphorylated | 1.14 (0.69–1.21) | 1.14 (0.99–1.44) | 6.03 (2.08–10.8)* | 0.90 (0.26–0.99)§ |
Total | 1.00 ± 0.41 | 0.66 ± 0.24 | 1.54 ± 0.44* | 1.12 ± 0.55 | |
p65 NF-kB | Phosphorylated | 1.00 ± 0.69 | 0.96 ± 0.45 | 1.03 ± 0.49 | 0.63 ± 0.60 |
Total | 1.00 ± 0.50 | 0.61 ± 0.17 | 0.90 ± 0.62 | 0.90 ± 0.88 | |
IκB | Phosphorylated | 1.00 ± 0.67 | 0.75 ± 0.38 | 1.53 ± 0.73 | 1.01 ± 0.85 |
Total | 1.00 ± 0.67 | 0.67 ± 0.26 | 3.67 ± 1.50* | 2.57 ± 1.56# |
Data as mean ± standard deviation or median and percentiles. W, Wistar rats; W-EX, exercised Wistar rats; SHR, spontaneously hypertensive rats; SHR-EX, exercised SHR; JNK, Jun N-terminal kinase; ERK, extracellular-signal-regulated kinase; p65 NF-κB, p65 subunit of nuclear factor kappa B; IκB, Inhibitor of nuclear factor kappa B. ANOVA for a 2 × 2 factorial design and Tukey or Kruskal–Wallis and Dunn; *p < 0.05 vs. W; #p < 0.05 vs. W-EX; §p < 0.05 vs. SHR.