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. 2021 Jun 3;12:690181. doi: 10.3389/fphar.2021.690181

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Copyright © 2021 Li, Zhang, Shi, Liao, Zhang, Gao, Xing and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CH25H is involved in cholesterol metabolism disorders in KOA. (A) Saffron Red & Fast green staining of cartilage tissue, 100×, Scale bar = 100 μm. (B) Total cholesterol, free cholesterol and cholesterol ester were detected in cartilage. (C,D) CH25H, CYP7B1, and RORα expression in catilage were analyzed via western blotting. The band intensity was quantified by normalizing to β-actin (n = 3). (E) CH25H and CYP7B1 expression in cartilage were analyzed via qRT-PCR. Quantitative data were presented as mean ± SD. *p < 0.05, **p < 0.01.