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. 2021 Jun 3;12:690181. doi: 10.3389/fphar.2021.690181

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Copyright © 2021 Li, Zhang, Shi, Liao, Zhang, Gao, Xing and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MiR-10a-3p regulates inflammation and extracellular matrix homeostasis in chondrocytes. (A) Concentrations of IL-1β and TNF-α in chondrocytes supernatant were detected by ELISA. (B,C) MMP3, MMP13, SOX9, and Collagen II expression in chondrocytes were analyzed via western blotting. The band intensity was quantified by normalizing to β-actin (n = 3). (D) MMP3, MMP13, SOX9, COL2α1, ADAMTS4, ADAMTS5, and Aggrecan expression in chondrocytes were analyzed via qRT-PCR. (E, F) MMP3, MMP13, SOX9, and Collagen II expression in chondrocytes were analyzed via western blotting. The band intensity was quantified by normalizing to β-actin (n = 3). (G) MMP3, MMP13, SOX9, COL2α1, ADAMTS4, ADAMTS5, and Aggrecan expression in chondrocytes were analyzed via qRT-PCR. Quantitative data were presented as mean ± SD. *p < 0.05, **p < 0.01.