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. 2021 Jun 3;11:683951. doi: 10.3389/fonc.2021.683951

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Copyright © 2021 Du, Miao, Jiang, Cao, Wang, Wang, Yu, Wang and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The dual regulatory function of CALU on TME. (A–D) The TIMER and MCP-COUNTER algorithms indicated the significant correlation of CALU with CD8 T cells (p<0.001, R=0.490), macrophages(p<0.001, R=0.570), endothelial cells (p<0.001, R=0.310) and CAFs (p<0.001, R=0.610). (E) CALU expression level positively correlated with the stromal (p<0.001, R=0.510), immune (p<0.001, R=0.290) and ESTIMATE scores (p<0.001, R=0.430) and negatively associated with tumor purity (p<0.001, R=-0.420). ***p<0.001.