Table 3.
Marker gene expression of ‘Fibroblasts’ and ‘myofibroblasts’ of TISCH database.
| Marker gene | Fibroblasts | Myofibroblasts | cell type marker | ||||
|---|---|---|---|---|---|---|---|
| Log2FC | Percentage(%) | Adjusted P-value | Log2FC | Percentage(%) | Adjusted P-value | ||
| PDGFRA | 0.77 | 41 | 2.58E-268 | — | — | — | Marker gene of iCAFs |
| CXCL12 | 0.64 | 25.7 | 1.39E-85 | — | — | — | |
| CFD | 2.26 | 29.9 | 2.03E-25 | — | — | — | |
| DPT | 1.42 | 47.9 | 0.00E+00 | — | — | — | |
| CXCL1 | 0.48 | 17.4 | 8.31E-10 | — | — | — | |
| ACTA2 | 2.03 | 72.2 | 8.48E-147 | 3.61 | 97.1 | 6.35E-146 | Marker gene of myCAFs |
| TAGLN | 2.84 | 85.4 | 2.78E-195 | 2.93 | 97.1 | 3.71E-127 | |
| MYL9 | 2.05 | 88.2 | 1.09E-103 | 2.71 | 98.6 | 1.03E-70 | |
| POSTN | 2.77 | 79.9 | 0.00E+00 | 0.56 | 35.7 | 2.71E-28 | |
| TPM2 | — | — | — | 2.33 | 91.4 | 1.12E-82 | |
The annotated ‘Fibroblasts’ expressed high levels of marker genes of inflammatory CAFs, and the ‘myofibroblasts’ expressed genes that indeed expressed by myofibroblasts as reported previously.