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. 2021 Jun 3;12:653901. doi: 10.3389/fphar.2021.653901

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Copyright © 2021 Zhang, Zhang, Wang, Han, Liu, Li, Chen, Liu, Wang, Tian, Zhao and Yan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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High-performance liquid chromatography (HPLC) chromatogram of the BCW extract. A representative HPLC chromatogram from three batches is shown. (A) HPLC chromatograms of mixed reference solutions of five standards: (i) gallic acid, (ii) protocatechuic acid, (iii) costunolide, (iv) dehydrocostus lactone, ( and (v) dehydrodiisoeugenol. (B) Five main chemical markers were identified in the BCW extract. The denotation peaks 1–5 were (i) gallic acid, (ii) protocatechuic acid, (iii) costunolide, (iv) dehydrocostus lactone, and (v) dehydrodiisoeugenol.