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. 2021 Jun 3;12:666231. doi: 10.3389/fimmu.2021.666231

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Copyright © 2021 Amitrano, Berry, Lim, Kim, Waugh, Wojtovich and Kim

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Activation of OptoMito-On increases CD8⁺ T cell migration. The velocity (A), displacement (B), track length (C), meandering index (D), and percent migrating cells (E) of Mock (or GFP) and OptoMito-On expressing Day 4 CD8⁺ T cells migrating on ICAM-1 + CXCL12. The percentage of migrating cells was calculated as the number of cells migrating 5-20 µm/min divided by the total number of cells in the field of view during the 20-minute movie. All movies received 500 nm illumination and were analyzed with Volocity software. All data shown as mean ± SEM and analyzed by a two-tailed unpaired t-test with Welch’s correction (A–D: includes four independent experiments, Mock: 271 cells, OptoMito-On: 312 cells; E : n = 4 movies on the same day). ns, not significant.