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. 2021 Jun 3;12:604229. doi: 10.3389/fgene.2021.604229

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Copyright © 2021 Chen, Wang, Cho, Zhou and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Risk signature with two m⁶A RNA methylation regulator genes in rectal cancer. (A) The heatmap of the expression profiles of the 17 m⁶A RNA methylation regulator genes in the TCGA-READ dataset (N = 10, T = 95). (B) The expression of the 17 m⁶A regulator genes in tumor and normal samples (unpaired T-tests). (C,D) The coefficients estimated by multivariate Cox regression via LASSO are presented. (E) Comparison of overall survival with different YTHDC2 expression. (F) Comparison of overall survival with different METTL14 expression. *P < 0.05, **P < 0.01, and ***P < 0.001.