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. 2021 Jun 3;12:671585. doi: 10.3389/fgene.2021.671585

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Copyright © 2021 Lu, Zhou, Zhang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PPI networks and functional enrichment analyses. (A) A network of LIMK1 and its co-expression genes. (B) Functional enrichment analyses of 11 involved genes. LIMK1 was associated with actin filament organization, regulation of actin filament-based process, and actin cytoskeleton organization. These genes were involved in purine ribonucleoside binding, GTP Binding, and GTPase Activity. (C–I) The correlation analyses between the expression of LIMK1 and co-expressed genes in lung adenocarcinoma.CFL1, cofilin-1; RHOA, transforming protein RhoA; CFL2, cofilin-2; CDC42, cell division control protein 42 homolog; RHOC, Rho-related GTP-binding protein RhoC; PAK1, serine/threonine-protein kinase PAK 1; ROCK1, Rho-associated protein kinase 1; RAC1, Ras-related C3 botulinum toxin substrate 1; RHOB, Rho-related GTP-binding protein RhoB; HSP90AA1, heat shock protein HSP 90-alpha.